Anti-Inflammatory, Radioprotective, and Longevity Enhancing Capabilities of Cerium Oxide Nanoparticles
AssigneeEdward Via Virginia College of Osteopathic Medicin
InventorsBeverly A. Rzigalinski, Ariane M. Clark
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Abstract
The present invention provides cerium oxide nanoparticles for use both in therapeutic compositions in vivo and in research in vitro. The cerium oxide nanoparticles are of a known range of sizes having biological properties that are reproducible and beneficial. Pharmaceutical and other compositions are provided, as are methods of treatment.
Claims32
1-93. (canceled)
Cerium oxide nanoparticles having a size range of from 11 nm to 500 nm.
Cerium oxide nanoparticles having a size range of less than 1 nm to about 500 nm, in an amount sufficient to provide a single dose of particles to an animal to reduce or eliminate clinical symptoms resulting from damage due to free radicals in cells of the animal, or to prevent such clinical symptoms.
Cerium oxide nanoparticles having a size range of less than 1 nm to about 500 nm, in an amount sufficient to provide a single dose of particles to an animal to reduce, eliminate, or prevent clinical symptoms resulting from inflammatory responses in cells of the immune system or to decrease the inflammatory capacity of cells of the immune system.
A medical prosthesis made from joint replacements or joint additives coated with or containing cerium oxide nanoparticles of a size of at least about 1 nm to 500 nm in an amount sufficient to reduce inflammation in the subject.
A method of determining the effects of one or more environmental stimuli on free radical production in a cell, said method comprising:
- contacting at least one cell with cerium oxide nanoparticles of a size of at least 11 nm to provide treated cells;
- optionally providing identical cells, but which are not contacted with cerium oxide nanoparticles to provide control cells;
- observing the treated and, where provided, control cells for detectable changes in free radical levels;
- and
- optionally, comparing the free radical levels in the treated and control cells.
Dependencies are inferred from the claim text.