Methods of treating or preventing biofilm associated infections with free available chlorine free available chlorine water
AssigneeOculus Innovative Sciences, Inc.
InventorsROBERT NORTHEY, Eileen Thatcher, Andres Gutierrez
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Abstract
The invention provides methods of treating or reducing the incidence of an infection in a mammal due to a biofilm associated infectious microorganism comprising administering a therapeutically effective amount of free available chlorine (FAC) water to a site populated with biofilm associated infectious microorganism.
Claims29
A method of treating or reducing the incidence of an infection in a mammal comprising administering a therapeutically effective amount of free available chlorine (FAC) water to a biofilm containing an infectious microorganism present on the surface of a tissue wherein:
- (a) the pH of the FAC water is from about 4.5 to about 7.7,
- (b) the concentration of oxychlorine species in the FAC water is at least about 30 mg/L, and
- (c) the tissue on which the biofilm is present is selected from the group consisting of lower and upper respiratory tract tissue, corneal tissue, inner ear tissue, urinary tract tissue, oral mucosa tissue, dental tissue and synovial tissue.
A method of reducing the incidence of an infection in a mammal associated with a medical device comprising contacting the medical device with an effective amount of free available chlorine (FAC) water to wherein:
- (a) the pH of the FAC water is from about 4.5 to about 7.7,
- (b) the concentration of oxychlorine species in the FAC water is at least about 30 mg/L, and
- (c) a biofilm containing an infectious microorganism present on the surface of the device.
A method for treating, reducing or preventing the incidence of a bacterial infection in a mammal comprising administering a therapeutically effective amount of FAC water to the site of an infection present on the surface of a tissue wherein the FAC water can reduce the concentration of bacteria in biofilms by at least about four logs (104) within about sixty minutes (60) of continuous exposure of the bacteria in biofilms to the FAC water.
Dependencies are inferred from the claim text.