Novel Adjuvant Compounds
AssigneeThe University Court of the University of Glasgow
InventorsTimothy John Mitchell, Lea-Ann Kirkham, Graeme James Cowan, Gillian Douce
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Abstract
The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.
Claims20
A method of generating an immune response against a peptide antigen, comprising administering to a subject a fusion protein comprising said peptide antigen and a cytolysin.
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Dependencies are inferred from the claim text.