Immunogens from uropathogenic escherichia coli
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsFrancesco Berlanda Scorza, Danilo Gomes Moriel, Jörg Hacker, Mariagrazia Pizza, Laura Serino, Maria Rita Fontana
Life of this patent
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Abstract
Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
Claims11
A polypeptide comprising:
- (a) an amino acid sequence selected from the group consisting of SEQ ID NOs 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167 and 168;
- (b) an amino acid sequence having at least 80% sequence identity to an amino acid sequence of (a);
- (c) an amino acid sequence which is a fragment of at least 10 consecutive amino acids from an amino acid sequence of (a);
- or (d) an amino acid sequence having at least 80% sequence identity to an amino acid sequence of (a) and including a fragment of at least 10 consecutive amino acids from an amino acid sequence of (a).
An immunogenic composition comprising one or more outer membrane vesicles (OMVs) expressing one or more polypeptides comprising:
- (a) an amino acid sequence selected from the group consisting of SEQ ID NOs 1, 2, 3, 4, 5, 6, and 7 (b) an amino acid sequence having at least 80% sequence identity to an amino acid sequence of (a);
- (c) an amino acid sequence which is a fragment of at least 10 consecutive amino acids from an amino acid sequence of (a);
- or (d) an amino acid sequence having at least 80% sequence identity to an amino acid sequence of (a) and including a fragment of at least 10 consecutive amino acids from an amino acid sequence of (a).
Dependencies are inferred from the claim text.