US 2010/0166787 A1Published application

Vaccines and methods for using the same

AssigneeThe Trustees of the University of Pennsylvania

InventorsDavid B Weiner, Jian Yan, Dominick Laddy

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Abstract

Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

Claims49

Dependent claims

A nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

SEQ ID NO:1;
fragments of SEQ ID NO:1;
sequences having at least 90% homology to SEQ ID NO:1;
fragments of sequences having at least 90% homology to SEQ ID NO:1;
SEQ ID NO:3;
fragments of SEQ ID NO:3;
sequences having at least 90% homology to SEQ ID NO:3;
fragments of sequences having at least 90% homology to SEQ ID NO:3;
SEQ ID NO:5;
fragments of SEQ ID NO:5;
sequences having at least 90% homology to SEQ ID NO:5;
fragments of sequences having at least 90% homology to SEQ ID NO:5;
SEQ ID NO:7;
fragments of SEQ ID NO:7;
sequences having at least 90% homology to SEQ ID NO:7;
fragments of sequences having at least 90% homology to SEQ ID NO:7;
SEQ ID NO:9;
fragments of SEQ ID NO:9;
sequences having at least 90% homology to SEQ ID NO:9;
fragments of sequences having at least 90% homology to SEQ ID NO:9;
SEQ ID NO:11;
fragments of SEQ ID NO:11;
sequences having at least 90% homology to SEQ ID NO:11;
fragments of sequences having at least 90% homology to SEQ ID NO:11;
SEQ ID NO:22;
fragments of SEQ ID NO:22;
sequences having at least 90% homology to SEQ ID NO:22;
fragments of sequences having at least 90% homology to SEQ ID NO:22;
SEQ ID NO:30;
fragments of SEQ ID NO:30;
sequences having at least 90% homology to SEQ ID NO:30;
fragments of sequences having at least 90% homology to SEQ ID NO:30;
SEQ ID NO:34;
fragments of SEQ ID NO:34;
sequences having at least 90% homology to SEQ ID NO:34;
fragments of sequences having at least 90% homology to SEQ ID NO:34;
SEQ ID NO:36;
fragments of SEQ ID NO:36;
sequences having at least 90% homology to SEQ ID NO:36;
fragments of sequences having at least 90% homology to SEQ ID NO:36;
SEQ ID NO:38;
fragments of SEQ ID NO:38;
sequences having at least 90% homology to SEQ ID NO:38;
fragments of sequences having at least 90% homology to SEQ ID NO:38;
SEQ ID NO:40;
fragments of SEQ ID NO:40;
sequences having at least 90% homology to SEQ ID NO:40;
fragments of sequences having at least 90% homology to SEQ ID NO:40;
SEQ ID NO:42;
fragments of SEQ ID NO:42;
sequences having at least 90% homology to SEQ ID NO:42;
and fragments of sequences having at least 90% homology to SEQ ID NO:42.

49 more elements

A nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

nucleotide sequences that encode SEQ ID NO:2;
nucleotide sequences that encode an amino acid sequences having at least 90% homology to SEQ ID NO:2;
fragments of nucleotide sequences that encode SEQ ID NO:2;
fragments of a nucleotide sequence that encode an amino acid sequence having at least 90% homology to SEQ ID NO:2;
nucleotide sequences that encode SEQ ID NO:4;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:4;
fragments of nucleotide sequences that encodes SEQ ID NO:4;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:4;
nucleotide sequences that encode SEQ ID NO:6;
nucleotide sequences that encode an amino acid sequences having at least 90% homology to SEQ ID NO:6;
fragments of nucleotide sequences that encode SEQ ID NO:6;
fragments of a nucleotide sequence that encode an amino acid sequence having at least 90% homology to SEQ ID NO:6;
nucleotide sequences that encode SEQ ID NO:8;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:8;
fragments of nucleotide sequences that encodes SEQ ID NO:8;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:8;
nucleotide sequences that encode SEQ ID NO:10;
nucleotide sequences that encode an amino acid sequences having at least 90% homology to SEQ ID NO:10;
fragments of nucleotide sequences that encode SEQ ID NO:10;
fragments of a nucleotide sequence that encode an amino acid sequence having at least 90% homology to SEQ ID NO:10;
nucleotide sequences that encode SEQ ID NO:12;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:12;
fragments of nucleotide sequences that encodes SEQ ID NO:12;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:12;
nucleotide sequences that encode SEQ ID NO:23;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:23;
fragments of nucleotide sequences that encodes SEQ ID NO:23;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:23;
nucleotide sequences that encode SEQ ID NO:31;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:31;
fragments of nucleotide sequences that encodes SEQ ID NO:31;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:31;
nucleotide sequences that encode SEQ ID NO:35;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:35;
fragments of nucleotide sequences that encodes SEQ ID NO:35;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:35;
nucleotide sequences that encode SEQ ID NO:37;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:37;
fragments of nucleotide sequences that encodes SEQ ID NO:37;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:37;
nucleotide sequences that encode SEQ ID NO:39;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:39;
fragments of nucleotide sequences that encodes SEQ ID NO:39;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:39;
nucleotide sequences that encode SEQ ID NO:41;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:41;
fragments of nucleotide sequences that encodes SEQ ID NO:41;
fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:41;
nucleotide sequences that encode SEQ ID NO:43;
nucleotide sequences that encodes an amino acid sequences having at least 90% homology to SEQ ID NO:43;
fragments of nucleotide sequences that encodes SEQ ID NO:43;
and fragments of nucleotide sequences that encodes an amino acid sequence having at least 90% homology to SEQ ID NO:43.

49 more elements

A protein comprising an amino acid sequence selected from the group consisting of:

SEQ ID NO:2, sequences having at least 90% homology to SEQ ID NO:2;
fragments of SEQ ID NO:2;
fragments of sequences having at least 90% homology to SEQ ID NO:2;
SEQ ID NO:4, sequences having at least 90% homology to SEQ ID NO:4;
fragments of SEQ ID NO:;
fragments of sequences having at least 90% homology to SEQ ID NO:4;
SEQ ID NO:6, sequences having at least 90% homology to SEQ ID NO:6;
fragments of SEQ ID NO:6;
fragments of sequences having at least 90% homology to SEQ ID NO:6;
SEQ ID NO:8, sequences having at least 90% homology to SEQ ID NO:8;
fragments of SEQ ID NO:8;
fragments of sequences having at least 90% homology to SEQ ID NO:8;
SEQ ID NO:10, sequences having at least 90% homology to SEQ ID NO:10;
fragments of SEQ ID NO:10;
fragments of sequences having at least 90% homology to SEQ ID NO:10;
SEQ ID NO:12, sequences having at least 90% homology to SEQ ID NO:12;
fragments of SEQ ID NO:12;
fragments of sequences having at least 90% homology to SEQ ID NO:12;
SEQ ID NO:23, sequences having at least 90% homology to SEQ ID NO:23;
fragments of SEQ ID NO:23;
fragments of sequences having at least 90% homology to SEQ ID NO:23;
SEQ ID NO:31, sequences having at least 90% homology to SEQ ID NO:31;
fragments of SEQ ID NO:31;
fragments of sequences having at least 90% homology to SEQ ID NO:31;
SEQ ID NO:35, sequences having at least 90% homology to SEQ ID NO:35;
fragments of SEQ ID NO:35;
fragments of sequences having at least 90% homology to SEQ ID NO:35;
SEQ ID NO:37, sequences having at least 90% homology to SEQ ID NO:37;
fragments of SEQ ID NO:37;
fragments of sequences having at least 90% homology to SEQ ID NO:37;
SEQ ID NO:39, sequences having at least 90% homology to SEQ ID NO:39;
fragments of SEQ ID NO:39;
fragments of sequences having at least 90% homology to SEQ ID NO:39;
SEQ ID NO:41, sequences having at least 90% homology to SEQ ID NO:41;
fragments of SEQ ID NO:41;
fragments of sequences having at least 90% homology to SEQ ID NO:41;
SEQ ID NO:43, sequences having at least 90% homology to SEQ ID NO:43;
fragments of SEQ ID NO:43;
and fragments of sequences having at least 90% homology to SEQ ID NO:43.

36 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/375,518Filed 30 Jul 2007
Priority: 28 Jul 2006
Published: 1 Jul 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification37 codes

C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses
A61K 39/0011
Vertebrate antigens: cancer antigens
A61K 39/001157
Enzymes: telomerase or TERT [telomerase reverse transcriptase]
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens

Family

Application60/833,856Us provisional application · filed 28 Jul 2006
Application60/833,861Us provisional application · filed 28 Jul 2006
Application60/890,352Us provisional application · filed 16 Feb 2007
US 8,168,769 B2Related patent
US 2010/0166787 A1This patent

From the US filing history. Foreign family members aren’t listed.

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