Method
AssigneeGlaxosmithkline Biologicals SA
InventorsPierre Raphael Dupont, Swann Romain Jean-Thomas Gaulis, Thibault Marc Helleputte
Life of this patent
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Abstract
Gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and new diagnostic kits and methods are provided. The gene expression profiles, microarrays, and new diagnostic kits and methods find use in the treatment of specific populations of cancer patients suffering from MAGE expressing tumours, the populations characterised by their gene expression profile.
Claims20
A method of classifying a patient as a responder or non-responder comprising the steps of:
- (a) determining the expression levels of one or more genes in a patient-derived sample, wherein the gene(s) are selected from Table 1;
- (b) classifying the patient to either a responder or non-responder group based on the expression levels of (a).
A method of characterising a patient as a responder or non-responder to therapy comprising the steps:
- (a) analysing a patient derived sample for differential expression of the gene products of one or more genes of Table 1, and
- (b) characterising the patient from which the sample was derived as a responder or non-responder, based on the results of step (a),
- wherein the characterisation step is optionally performed by reference or comparison to a standard.
A microarray comprising one or more polynucleotide probes complementary and hybridisable to a sequence of the gene product of at least one gene selected from the group of gene products listed in Table 1, in which the polynucleotide probes complementary and hybridisable to a sequence of the gene product of at least one gene selected from the group consisting of the gene products listed in Table 1 constitute at least 50% of the probes or probe sets on said microarray.
A method of treating a patient characterised as a responder comprising the steps of:
- (a) determining the expression levels of one or more gene products in a patient-derived sample, wherein the gene products are selected from the group of gene products s set forth Table 1;
- (b) classifying the patient to either a responder or non-responder group based on the expression levels of (a);
- and
- (c) if the patient is classified as a responder, administering a composition comprising a tumour associated antigen to the patient.
A method of treating a patient characterised as a responder comprising the steps of:
- (a) analysing a patient derived sample for differential expression of the gene products of one or more genes of Table 1;
- (b) characterising the patient from which the sample was derived as a responder or non-responder, based on the results of step (a), wherein the characterisation step is optionally performed by reference or comparison to a standard;
- and
- (c) if the patient is classified as a responder, administering a composition comprising a tumour associated antigen to the patient.
Dependencies are inferred from the claim text.