Antagonists of bacterial sequences
AssigneeNational University of Singapore
InventorVOLKER PATZEL
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Abstract
The present invention refers to antagonist molecules, particularly nucleic acid effector molecules directed against a bacterial RNA.
Claims16
An antagonist directed against a bacterial RNA or a precursor thereof, wherein the bacterial RNA has a stem-loop secondary structure.
A method for the prevention and/or treatment of a disorder caused by or associated with a bacterial pathogen, comprising administering to a subject in need thereof a therapeutically effective amount of an antagonist directed against an RNA from said bacterial pathogen or against a precursor of said RNA, wherein said RNA has a stem-loop secondary structure.
Use of a bacterial RNA having a stem-loop secondary structure, which resembles a miRNA structure or a miRNA molecule derived from such a structure as a therapeutic or diagnostic agent.
A screening method for identifying and/or characterizing compounds which act as antagonists against a bacterial RNA or a precursor thereof, wherein the bacterial RNA has a stem-loop secondary structure, which resembles a micro-RNA (miRNA) structure.
Dependencies are inferred from the claim text.