Metallothionein-Derived Peptide Fragments
AssigneeUniversity of Tasmania
InventorsVladimir Berezin, Elisabeth Bock, Milena Penkowa
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Abstract
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
Claims82
A peptide comprising at most 25 contiguous amino acid residues comprising an amino acid motif of the formula:
- S/D/E-(x)n-S/D/E-K/S, wherein
- (x)n is a sequence of any amino acid residues, and
- n is an integer from 4 to 6.
A peptide consisting of a sequence selected from SEQ ID NOs 1-8.
A peptide which is a fragment of a metallothionein, said peptide being a sequence of at most 20 amino acid residues, said sequence is capable of stimulating neurite outgrowth, stimulating neuronal survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammation.
(canceled)
Dependencies are inferred from the claim text.