Novel antibody molecules and nucleic acids
OwnerJames Burnie, Philipp Wechnerinventors
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Abstract
An scFv peptide comprising a VH domain and a VL domain linked by an amino acid spacer is disclosed. The VH domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 64. The VL domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 66. The scFv peptide also comprises the substitution or deletion of an amino acid in the VH domain at the position corresponding to C28.
Claims26
An scFv peptide comprising a VH domain and a VL domain, wherein the VH domain comprises the amino acid sequence set forth in SEQ ID NO:64 and the VL domain comprises the amino acid sequence set forth in SEQ ID NO:66, and wherein the scFv peptide comprises a substitution of an amino acid in the VH domain at the position corresponding to C28 of SEQ ID NO:64.
An scFv peptide, comprising an amino acid sequence selected from the group consisting of SEQ ID NO:8, 10 and 14, wherein Xaa denotes an amino acid residue other than cysteine and wherein the N-terminal methionine residue may optionally be cleaved off.
An scFv peptide comprising the amino acid sequence as set forth in SEQ ID NO:10, wherein Xaa is tyrosine or serine and wherein the N-terminal methionine residue may optionally be cleaved off.
Dependencies are inferred from the claim text.