Cancer therapy using whole glucan particles and antibodies
AssigneesBiopolymer Engineering, Inc. d/b/a Biothera, University of Louisville Research Foundation, Inc.
InventorsGary R. Ostroff, Gordon D. Ross, Trunetta Jo Dockter Ross
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Abstract
The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.
Claims18
A method of suppressing or eliminating tumor cells, comprising:
- administering to a subject in need of treatment a therapeutically effective amount of insoluble β (1,3;
- 1,6) whole glucan particles and at least one complement activating anti-tumor antibody;
- wherein the glucan and antibody suppresses or eliminates tumor cells.
Use of insoluble β (1,3;
- 1,6) whole glucan particles and complement activating anti-tumor antibody for the manufacture of a medicament for use in treating a neoplastic cell, wherein the combination of glucan and antibody retards the growth of the cell.
A method of treating a neoplastic cell comprising administering to said cell a therapeutically effective dose of insoluble β (1,3;
- 1,6) whole glucan particles and a complement activating antibody specific to the neoplastic cell.
A method of suppressing or eliminating tumor cells, comprising:
- administering to a subject in need of treatment a therapeutically effective amount of insoluble β (1,3;
- 1,6) whole glucan particles wherein the whole glucan particles is taken up by macrophages, degraded and the degraded fragments bind to neutrophils in the bone marrow and through chemotaxis migrate and bind to antibody coated tumor cells where complement has been activated via iC3b deposited the tumor cells by a naturally occurring complement activating antibody, wherein the binding of glucan to the iC3b tumor cells results in suppressing or eliminating the tumor cells.
A method of suppressing or eliminating tumor cells, comprising:
- administering to a subject in need of treatment a therapeutically effective amount of insoluble β (1,3;
- 1,6) whole glucan particles and at least one complement activating anti-tumor antibody;
- wherein the glucan and antibody suppresses or eliminates tumor cells and provided that the glucan is not derived from barley.
Dependencies are inferred from the claim text.