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AssigneeDana-Farber Cancer Institute, Inc.
InventorKwok-Kin Wong
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The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described.
A method of treating tyrosine kinase inhibitor resistant EGFR-mediated disease in a mammal, wherein said resistant EGFR-mediated disease is a result of a secondary mutation in EGFR to generate a mutant EGFR and wherein said mutation is distinct from the EGFR vIII mutation, comprising administering to said mammal an effective amount of an anti-EGFR antibody capable of binding to and inhibiting the mutant EGFR.
A method for reducing EGFR-mediated tumor growth in a cancer patient, wherein said cancer patient has been previously treated with one or more tyrosine kinase inhibitor and has developed recurrent disease and tumor growth, comprising administering to said patient an effective amount of an anti-EGFR antibody such that the recurrent disease and tumor growth is inhibited and reduced.
A method of treating EGFR-mediated cancer in a mammal comprising administering to said mammal a tyrosine kinase inhibitor and anti-EGFR antibody, wherein said anti-EGFR antibody is administered after treatment with the tyrosine kinase inhibitor as a second line of therapy to inhibit potential secondary mutant EGFRs resistant to tyrosine kinase inhibitors.
Dependencies are inferred from the claim text.