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AssigneesGenentech, Inc., Biogen Idec MA Inc.
InventorsRobert F. Kelley, Amy Yijuan Shen, Dorothea Reilly, Mark S. Dennis, Germaine Fuh, Chingwei V. Lee, Christine M. Ambrose, Jeffrey S. Thompson
Estimating the term…
The present invention relates to novel BR3 binding antibodies having altered Fc effector function and/or having a mature core carbohydrate structure in the Fc region which lacks fiicose. The present invention also relates to the use of those BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
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An anti-BR3 antibody having an Fc region wherein said anti-BR3 antibody is afucosylated.
The anti-BR3 antibody composition of claim 39, wherein said composition comprises at least 4% afucosylated-anti-BR3 antibodies.
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Dependencies are inferred from the claim text.