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AssigneeRoche Palo Alto LLC
InventorsJoseph Endl, Elsie M. Eugui, Maria Elena Fuentes, Yvo Graus, Aran Frank Labrijn, Martin Lanzendoerfer, Paul Parren, Frank Rebers, Ralf Schumacher, Stefan Seeber, Jan Van de Winkel, Martine Van Vugt
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This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
An antibody, characterized in that said antibody binds OX40L, contains a Fc part derived from human origin, the light chain variable domain defined by amino acid sequence SEQ ID NO:1 and the heavy chain variable domain defined by SEQ ID NO:2, and does not bind complement factor C1q.
An antibody, characterized in that said antibody binds OX40L and that the antibody comprises a variable region combination including the light chain variable domain defined by amino acid sequence SEQ ID NO:1 and the heavy chain variable domain defined by SEQ ID NO:2.
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An antibody, characterized in that it is produced by the cell line
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Dependencies are inferred from the claim text.