US 2010/0166732 A1 · SMALL STREPTOCOCCUS PYOGENES ANTIGENS AND THEIR USE

Abstract

The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes (S. pyogenes) of any of the SEQ ID NOS: 1 to 7 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

Claims30

Dependent claims

A peptide consisting of one antigen of S. pyogenes selected from the group consisting of SEQ ID NO:

4, SEQ ID NO:
1, SEQ ID NO:
2, SEQ ID NO:
7, SEQ ID NO:
5, SEQ ID NO:
6 and SEQ ID NO:
3 or a functional active variant of one antigen of S. pyogenes selected from the group consisting of the SEQ ID NO:
4, SEQ ID NO:
1, SEQ ID NO:
2, SEQ ID NO:
7, SEQ ID NO:
5, SEQ ID NO:
6 and SEQ ID NO:
3.

11 more elements

A peptide consisting of one antigen of S. pyogenes selected from the group consisting of SEQ ID NO:

4, SEQ ID NO:
1, SEQ ID NO:
2, SEQ ID NO:
7, SEQ ID NO:
5, SEQ ID NO:
6 and SEQ ID NO:
3 or a functional active variant of one antigen of S. pyogenes selected from the group consisting of the SEQ ID NO:
4, SEQ ID NO:
1, SEQ ID NO:
2, SEQ ID NO:
7, SEQ ID NO:
5, SEQ ID NO:
6 or SEQ ID NO:
3, and
a) 0 to 350 additional amino acid residue(s) if the antigen is SEQ ID NO:
1;
or
b) 0 to 200 additional amino acid residue(s) if the antigen is SEQ ID NO:
2;
or
c) 0 to 100 additional amino acid residue(s) if the antigen is that of SEQ ID NO:
3;
or
d) 0 to 150 additional amino acid residue(s) if the antigen is that of SEQ ID NO:
4;
or
e) 0 to 450 additional amino acid residue(s) if the antigen is SEQ ID NO:
5;
or
f) 0 to 250 additional amino acid residue(s) if the antigen is SEQ ID NO:
6;
or
g) 0 to 250 additional amino acid residue(s) if the antigen is SEQ ID NO:
7.

31 more elements

Dependencies are inferred from the claim text.

Small streptococcus pyogenes antigens and their use

Life of this patent

Small streptococcus pyogenes antigens and their use

Life of this patent

Abstract

Claims30