Loading patent…
AssigneesGovernment of the United States of America, repres, The Regents of the University of California
InventorsKent W. Hunter, Nigel Crawford, Douglas R. Lowy, Xiaolan Qian, Hoda Anton-Culver, Agryrios Ziogas
Estimating the term…
Disclosed are methods involving the administration of an extracellular matrix (ECM)/metastasis modifier gene, e.g., Anakin, Necdin, CentaurinD3 (CentD3), Csf1r, Brd4, Pi16, and Luc7l, for the prevention or inhibition of metastasis or of tumor growth. Further disclosed are methods of characterizing a tumor or cancer in a subject comprising detecting (i) a single nucleotide polymorphism (SNP) in an Anakin gene or a Brd4 gene of the subject, (ii) an amino acid substitution in an Anakin protein in the subject, or (iii) a level of expression of an Anakin gene or a Brd4 gene in the subject. Methods of screening a compound for anti-cancer activity and use of a compound with anti-cancer activity for the preparation of a medicament to treat or prevent cancer in a subject are also disclosed. Also disclosed is a method of inhibiting Sipa-1 in a subject.
(canceled)
A pharmaceutical composition comprising (i) a nucleic acid comprising a nucleotide sequence encoding a protein, (ii) a vector comprising the nucleic acid, (iii) a host cell comprising the vector, (iv) a gene product, or (v) a combination thereof, wherein the protein or gene product are encoded by a gene selected from the group consisting of:
A pharmaceutical composition comprising (i) a nucleic acid comprising a nucleotide sequence encoding a protein, (ii) a vector comprising the nucleic acid, (iii) a host cell comprising the vector, (iv) a gene product, or (v) a combination thereof, wherein the protein or gene product are encoded by a gene selected from the group consisting of:
A method of characterizing a tumor or a cancer in a subject comprising detecting (i) a single nucleotide polymorphism (SNP) in an Anakin gene or a Brd4 gene of the subject, (ii) an amino acid substitution in an Anakin protein in the subject, or (iii) an expression level of an Anakin gene or a Brd4 gene in the subject, whereupon the tumor or cancer is characterized.
An isolated, purified, or synthetic nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs:
An isolated, purified, or synthetic antibody, or antigen binding portion thereof, which specifically binds to a murine Anakin protein or an Anakin allelic variant.
A method for screening a compound for anti-cancer activity comprising (a) providing a cell that (i) under-expression a nucleic acid comprising a nucleotide sequence encoding an Anakin protein or a Brd4 protein or (ii) comprises an Anakin or Brd4 allelic variant, (b) contacting the cell with a compound of interest, and (c) assaying for anti-cancer activity.
(canceled)
A method of inhibiting Sipa-1 in a subject in need thereof comprising administering to the subject an effective amount of (i) a nucleic acid comprising a nucleotide sequence encoding an Anakin protein, (ii) a vector comprising the nucleic acid, (iii) a host cell comprising the vector, (iv) an Anakin gene product, or (v) a combination thereof.
Dependencies are inferred from the claim text.