Methods and compositions for inhibition of viral replication
OwnerMargo A. Brinton, Mohamed M. Emara +1inventors
InventorsMargo A. Brinton, Mohamed M. Emara, Wei Li
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Abstract
The present invention is directed to methods and compositions that are effective in the inhibition of viral replication. In particular, the methods and compositions are effective at interfering with the activity of host cell proteins required in viral replication. For example, an embodiment of the invention is directed to inhibition of flavivirus replication wherein the replication is affected by changing the normal interactions of the host cell protein TIAR or TIA-1.
Claims17
A method of inhibiting replication of a flavivirus, comprising,
- administering an effective amount of a composition;
- and
- inhibiting flavivirus replication by inhibiting or interfering with at least one host cell protein associated with replication of a flavivirus
A method of inhibiting replication of a flavivirus, comprising,
- administering an effective amount of a composition;
- and
- inhibiting flavivirus replication by inhibiting or interfering with the interaction or association of at least one host cell protein and at least one viral protein.
A method of inhibiting replication of a flavivirus, comprising,
- administering an effective amount of a composition;
- and
- inhibiting flavivirus replication by inhibiting or interfering with a host cell signaling pathway.
Dependencies are inferred from the claim text.