Multivalent Heterobifunctional Polymers And Methods Of Their Use

A multivalent heterobifunctional polymer for binding to a biological target exhibiting biological activity and to an effector template which can affect the biological activity of the biological target or detect the presence of the biological target, the polymer having the formula:

• wherein “X” represents a polymeric backbone of the multivalent polymer;
• “MO” represents a heterobifunctional ligand, wherein “M” represents a first functionality capable of binding to the biological target and “O” represents a second functionality capable of binding to the effector template;
• “Y” represents an optional linker that connects “MO” to or into the polymeric backbone;
• and
• “n” represents an integer selected such that a sufficient number of heterobifunctional ligands are presented in the polymer for an intended use.

A multivalent heterobifunctional polymer for binding to a biological target exhibiting biological activity and to an effector template which can affect the biological activity of the biological target or detect the presence of the biological target, the polymer having the formula:

• wherein “X” represents a polymeric backbone of the multivalent polymer;
• “M-N-O” represents a heterobifunctional ligand, wherein “M” represents a first functionality capable of binding to the biological target, “O” represents a second functionality capable of binding to the effector template, and “N” represents a linker connecting “M” and “N”;
• “Y” represents an optional linker that connects the heterobifunctional ligand to or into the polymeric backbone;
• and
• “n” represents an integer selected such that a sufficient number of heterobifunctional ligands are presented in the polymer for an intended use.