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US 2010/0166669 A1Published application
Methods of imaging inflammation in pancreatic islets
AssigneesJoslin Diabetes Center, Inc., The General Hospital Corporation
InventorsDiane J. Mathis, Ralph Weissleder, Umar Mahmood, Christophe O. Benoist
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Abstract
Described are non-invasive methods for imaging pancreatic inflammation in living mammals using Magnetic Nanoparticle Probes (MNPs).
Claims30
A method of imaging inflammation in a pancreatic tissue of a living mammal in vivo, the method comprising:
- administering a detectable amount of a composition comprising Magnetic Nanoparticle Probes (MNPs) or derivatives thereof to a living mammal;
- and
- detecting MNPs in the pancreatic tissue of the mammal,
- thereby imaging inflammation in the pancreatic tissue.
1 more element
A method of evaluating the efficacy of a candidate treatment for pancreatic inflammation in a subject, the method comprising:
- selecting a subject;
- administering a candidate therapeutic intervention to the subject;
- and
- obtaining an in vivo image of inflammation in a pancreatic tissue of the subject, wherein the presence, absence, or level of inflammation in the pancreatic tissue is indicative of the efficacy of the candidate treatment.
1 more element
A method of evaluating pancreatic inflammation in a subject, the method comprising:
- administering a detectable amount of a composition comprising Magnetic Nanoparticle Probes (MNPs) or derivatives thereof to the mammal;
- obtaining a magnetic resonance image (MRI) of MNPs in a pancreatic tissue of the mammal;
- and
- deriving a value relevant to inflammation from the image of MNPs;
- thereby evaluating pancreatic inflammation in the subject.
2 more elements
Dependencies are inferred from the claim text.