Magnetic resonance imaging method using vanadyl-based contrast agents
AssigneeThe University of Chicago
InventorsDevkumar Mustafi, Gregory S. Karczmar, Marvin W. Makinen, Marta Zamora, Edward S. Foxley
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Abstract
A new, clinically applicable magnetic resonance imaging (MRI) method has been developed for in vivo imaging of a population of cells in a subject based on a class of paramagnetic divalent vanadyl-based contrast agents. The method includes administering to a subject a VO2+-based contrast agent and monitoring distribution of the VO2+-based contrast agent in the subject using magnetic resonance imaging.
Claims39
A method of in vivo imaging a population of cells in a subject comprising:
- administering a VO2+-based contrast agent to the subject;
- and
- monitoring distribution of the VO2+-based contrast agent in the subject using magnetic resonance imaging.
A method of detecting cancer cells in a subject comprising:
- obtaining a first magnetic resonance image of a region of the subject;
- administering a VO2+-based contrast agent to the subject;
- obtaining a second magnetic resonance image of the region;
- and
- comparing the first and second magnetic resonance images.
A method of detecting cancer cells in a subject comprising:
- administering a VO2+-based contrast agent to the subject;
- obtaining a magnetic resonance image of the subject;
- and
- identifying regions of enhanced contrast in the magnetic resonance image.
A method of enhancing magnetic resonance imageability of a subject, comprising administering to the subject an amount of a VO2+-based contrast agent effective to enhance a magnetic resonance image.
A composition comprising:
- a VO2+-based contrast agent;
- and
- a physiologically acceptable organic solvent;
- and
- a physiologically acceptable buffer.
A composition comprising:
- a VO2+-based contrast agent;
- and
- a physiologically acceptable carrier,
- wherein the VO2+-based contrast agent is present in a concentration of at least about 1 mM.
A compound having the formula:
Dependencies are inferred from the claim text.