Monkey homolog of human oncostatin m
AssigneeCentocor Ortho Biotech Inc.
InventorsAdam Cotty, Michael Naso
Life of this patent
Estimating the term…
Abstract
Cytokine oncostatin M nucleic acids from Cynomolgus monkey are useful for expression of oncostatin M proteins that are functional homologs of human oncostatin M. The nucleic acids and proteins produced therefrom are useful in screening and safety testing of oncostatin M, the generation and testing of oncostatin M modulators and related activities.
Claims19
An isolated polynucleotide comprising a nucleotide sequence or a complementary sequence thereof encoding a polypeptide comprising the amino acid sequence shown in SEQ ID NO:
- 2.
An isolated polynucleotide comprising the nucleotide sequence shown in SEQ ID NO:
- 1 from positions 76 to 702 or a complementary sequence thereof.
An isolated recombinant vector comprising a polynucleotide having the nucleotide sequence shown in SEQ ID NO:
- 1.
An isolated polypeptide comprising a polypeptide having the sequence shown in SEQ ID NO:
- 2 from residues 26 to 234.
An isolated polypeptide comprising a polypeptide having the sequence shown in SEQ ID NO:
- 2 from residues 1 to 234.
An isolated polypeptide comprising a polypeptide having the sequence shown in SEQ ID NO:
- 2.
A method for determining cross-reactivity of a human OSM (SEQ ID NO:
- 6) modulator with cyno OSM comprising:
- a. providing an OSM modulator and a cyno OSM isolated polypeptide comprising the sequence shown in SEQ ID NO:
- 2 from residues 26 to 234;
- b. contacting the OSM modulator with the cyno OSM isolated polypeptide;
- and
- c. determining whether the OSM modulator binds to the cyno OSM isolated polypeptide.
A method for assessing the safety of a OSM modulator comprising:
- a. providing a OSM modulator, a first Macaca spp. monkey and a second Macaca spp. monkey;
- b. administering the OSM modulator to the first Macaca spp. monkey;
- and
- c. determining whether the first Macaca spp. monkey is presenting a deleterious symptom relative to the second Macaca spp. monkey, where presentation of a deleterious symptom by the first Macaca spp. monkey shows the OSM modulator is potentially unsafe for use in humans and a lack of presentation of a deleterious symptom by the first Macaca spp. monkey shows the OSM therapeutic is potentially safe for use in humans.
Dependencies are inferred from the claim text.