Compositions of high specific activity sn-117m and methods of preparing the same
AssigneeClear Vascular, Inc.
InventorsNigel Raymond Stevenson, Ian Martin Horn
Life of this patent
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Abstract
Compositions of high specific activity 117mSn with specific activity of greater than 100 Ci/g Sn and methods of producing the same. The method includes exposing 116Cd to an α-particle beam of sufficient incident kinetic energy and duration to convert a portion of the 116Cd to 117mSn to form an irradiated material. The irradiated material is dissolved to form an intermediate solution containing 117mSn and 116Cd. The 117mSn is separated from the 116Cd to yield high specific activity 117mSn.
Claims33
A method of preparing a high-specific-activity 117mSn composition, the method comprising:
- exposing a target layer enriched in 116Cd to an α-particle ion beam with an incident kinetic energy of about 30 MeV to about 60 MeV to convert a portion of the 116Cd in the target layer to 117mSn;
- dissolving the target layer to form an intermediate solution containing the 117mSn and the 116Cd;
- preparing an ion exchange resin column;
- loading the intermediate solution onto the ion exchange resin column;
- eluting the 117mSn and the 116Cd from the ion exchange resin column with an eluent solution to separate at least a portion of the 117mSn from at least a portion of the 116Cd;
- and
- collecting at least a portion of the eluent solution discharged from the ion exchange resin column to provide a product enriched in the 117mSn.
A composition of matter comprising:
- 117mSn with a specific activity greater than 100 Ci/g, and cadmium,
- wherein a mass ratio of all cadmium isotopes in the composition to all tin isotopes in the composition is less than 15,000:1.
A high-specific-activity 117mSn composition made by a process comprising
- exposing a target layer enriched in 116Cd to an α-particle ion beam with an incident kinetic energy of about 30 MeV to about 60 MeV to convert a portion of the 116Cd in the target layer to 117mSn;
- dissolving the target layer to form an intermediate solution containing the 117mSn and the 116Cd;
- preparing an ion exchange resin column;
- loading the intermediate solution onto the ion exchange resin column;
- eluting the 117mSn and the 116Cd from the ion exchange resin column with an eluent solution to separate at least a portion of the 117mSn from at least a portion of the 116Cd;
- and
- collecting at least a portion of the eluent solution discharged from the ion exchange resin column to provide a product enriched in the 117mSn.
A method of preparing a high-specific-activity 117mSn composition, the method comprising:
- exposing a target layer enriched in 116Cd to an α-particle ion beam with an incident kinetic energy of about 30 MeV to about 60 MeV to convert a portion of the 116Cd in the target layer to 117mSn;
- dissolving the target layer to form an intermediate solution containing the 117mSn and the 116Cd;
- and
- separating at least a portion of the 117mSn from at least a portion of the 116Cd by partitioning the intermediate solution between an organic solvent layer and an aqueous layer to produce a product enriched in the 117mSn.
A high-specific-activity 117mSn composition made by a process comprising:
- exposing a target layer enriched in 116Cd to an α-particle ion beam with an incident kinetic energy of about 30 MeV to about 60 MeV to convert a portion of the 116Cd in the target layer to 117mSn;
- dissolving the target layer to form an intermediate solution containing the 117mSn and the 116Cd;
- and
- separating a portion of the 117mSn from a portion of the 116Cd by partitioning the intermediate solution between an organic solvent layer and an aqueous layer to produce a product enriched in the 117mSn.
Dependencies are inferred from the claim text.