Radiotherapeutic High Specific Activity Tin-117m and Methods of Use
OwnerMarlene OLIVERinventor
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Abstract
The present invention provides a radiotherapeutic composition comprising a high specific activity tin-117m source of radiotherapeutic atomic electrons and a delivery vehicle, e.g., a chelator or nanosphere or microsphere effective to contain tin-117m therein. The present invention also provides a targeting moiety linked to the delivery vehicle. Further provided are methods of treating a bone-associated pathophysiological condition or imaging the same using the high specific activity radiotherapeutic compositions.
Claims42
A radiotherapeutic composition, comprising:
- a high specific activity tin-117m source of radiotherapeutic atomic electrons;
- and
- a delivery vehicle effective to contain tin-117m therein.
A method for treating a bone-associated pathological condition in a subject, comprising:
- administering the radiotherapeutic composition of claim ? to the subject wherein said radiotherapeutic atomic electrons emitted by the high specific activity tin-117m comprising said composition destroys cells characteristic of the bone-associated pathological condition upon delivery thereto thereby treating the pathophysiological bone condition.
A radiotherapeutic composition, comprising:
- a high specific activity tin-117m source of radiotherapeutic atomic electrons;
- and
- a nanosphere or microsphere encapsulating said tin-117m.
A radiotherapeutic composition, comprising:
- a high specific activity tin-117m source of radiotherapeutic atomic electrons;
- and
- a chelator of tin-117m.
Dependencies are inferred from the claim text.