Printable hydrogels for biosensors
AssigneeSanofi-Aventis Deutschland GmbH
InventorNorbert Bartetzko
Life of this patent
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Abstract
Methods and apparatus are provided for manufacturing an analyte detecting device. In one embodiment, the method comprises providing a substrate, applying a plurality of layer of materials on said substrate; applying a layer containing at least one mediator; and screen printing a hydrogel on the layer.
Claims34
A method of manufacturing an analyte detecting device, said method comprising:
- providing a substrate;
- applying a plurality of layers of materials on said substrate, wherein said layers form an electrode device;
- and
- screen printing a hydrogel on said layers.
A method manufacturing an analyte detecting device, said method comprising:
- providing a substrate;
- coating analyte detecting member surfaces/electrodes on said substrate with a cross-linkable hydrophilic polymer dispersion containing at least one of the following:
- a hydrophilic monomer mixture, a low molecular weight cross-linker and/or a hydrophilic high molecular weight polymer and preferably with an initiator.
A compound for use on an analyte detecting device, said compound comprising:
- a cross-linkable hydrophilic polymer dispersion containing a hydrophilic monomer mixture, a low molecular weight cross-linker and a hydrophilic high molecular weight polymer and preferably with an initiator.
The compound as described in claim 6 wherein the concentration as well as the molecular weight of the cross-linker as described in claim 17 as well as the degree of vinyl fictionalizations of the macromer as decried in claim 14 determines the porosity of the gel, which allows entrapment or permeation of the biological active species.
A method of manufacturing an analyte detecting device, said method comprising:
- stencil or screen-printing a hydrophilic coating that contains at least one of the following:
- a hydrophilic polymerbinder, a surface-active compound, and a solvent.
A method of manufacturing an analyte detecting device, said method comprising:
- stencil or screen-printing a hydrophilic coating that contains at least a hydrophilic polymerbinder, surface-active compound, defoamer and a solvent.
A method of manufacturing an analyte detecting device, said method comprising:
- stencil or screen-printing a hydrophilic coating that contains at least one of the following:
- a hydrophilic polymerbinder, surface-active compound, defoamer, retarder and a solvent.
A device comprising:
- a substrate;
- at least one electrically conductive lead line formed on the substrate;
- an insulating layer;
- a least one working electrode and at least one counterelectrode each formed to contact at least one electrically conductive lead line, wherein an upper portion of the working electrode has a width greater than a lower portion of the electrode;
- a hydrogel layer formed over the electrode;
- and
- a sample capture structure coupled and positioned to deliver fluid to the hydrogel layer.
Dependencies are inferred from the claim text.