Quantitative single image-based magnetization transfer weighted imaging using an inter-subject normalization reference within the image

An MRI system, comprising:

• a main magnet;
• a gradient coil;
• an RF coil;
• and
• a computer having a computer readable medium encoded with a program for acquiring an MTw image of the tissue, the MTw image having a plurality of voxels, wherein each voxel has a corresponding MR signal;
• identifying a reference region of voxels within the plurality of voxels, wherein the region of voxels corresponds to a reference material having a minimal magnetization transfer effect;
• computing a reference MR signal corresponding to the region of voxels;
• and computing an MTCSF image, based on the MR image and the reference MR signal.

A method for quantifying demyelination in a spinal cord, comprising:

• acquiring an MTw image of the spinal cord, the MTw image having a plurality of voxels, wherein each voxel has a corresponding MR signal;
• identifying a reference region of voxels within the plurality of voxels, wherein the region of voxels corresponds to cerebrospinal fluid;
• computing a reference MR signal corresponding to the region of voxels;
• and
• computing a normalized MT weighted image, based on the ratio of the MTw image and the reference MR signal.