System for Detecting Nanoparticles Using Modulated Surface Plasmon Resonance
AssigneeThe University of Toledo
InventorsRosa A. Lukaszew, Xuefei Huang
Life of this patent
Estimating the term…
Abstract
A method and system for detecting magnetic nanoparticles include measuring a magneto-optical enhancement of the plasmon absorption in the optical response.
Claims52
A system for detecting magnetic nanoparticles comprising measuring magneto-optical enhancement of optical plasmon absorption response in one or more nanoparticles.
A system comprising an array having nanoclusters of magnetic nanoparticles embedded on a metallic or dielectric thin film matrix.
A system for making magnetic glyco-nanoparticles comprising attaching one or more glycoconjugates to magnetic nanoparticles.
A system for detecting magnetic particles, comprising a sensing material having a matrix having implanted, deposited or patterned therein one or more magnetic nanoparticles or thin films, the matrix being capable of allowing the magnetic metallic nanoparticles to exhibit plasmon-like resonances and magneto-optical properties, and having binding nanoparticles deposited on the surface of the sensing material.
A system for detecting an analyte capable of binding with one or more carbohydrates or carbohydrate moieties comprising aggregating glyco-nanoparticles through multivalent interactions.
A system for detecting magnetic glyco-nanoparticles comprising:
- measuring a spectral magneto-optical response (θK vs v) of the glyco-nanoparticles using a magneto-optical effect;
- measuring an incident angle in reflection geometry with an alternating magnetic field applied;
- and,
- characterizing the magneto-optical response of the magnetic glyco-nanoparticles in media using a Faraday effect in transmission geometry.
A system for detecting the presence of pathogenic cells in a medium believed to contain one or more pathogenic cells, comprising:
- mixing magnetic glyco-nanoparticles with the medium, whereby a glyco-nanoparticle-pathogen complex is formed if any pathogenic cells are present in the medium;
- separating the glyco-nanoparticle-pathogen complex from the media;
- and,
- measuring a response of the glyco-nanoparticle-pathogen complex.
A system using a glyco-nanoparticle-pathogen complex as an anti-infectious agent comprising:
- mixing magnetic glyco-nanoparticles with at least one medium believed to contain cells of one or more pathogenic agents, whereby the magnetic glyco-nanoparticles attach to cells of the pathogenic agent;
- and
- separating the cells from the medium.
A system for evaluating one or more of magnetic and magneto-optical characterizations using magneto-optical effect, the system comprising:
- a device for measuring reflection geometries using fixed frequency light with variable incidence angle and an alternating magnetic field applied;
- and,
- a device for finding an optimum frequency for observation of a plasmon-enhanced magneto-optical effect using spectral determination of θK in reflection geometry.
A system for detecting magnetic glyco-nanoparticles comprising:
- a device configured for measuring a spectral magneto-optical response (θK vs v) of the glyco-nanoparticles using a magneto optical effect;
- a device configured for measuring an incident angle in reflection geometry with an alternating magnetic filed applied;
- and,
- a device configured for characterizing the magneto-optical response of the magnetic glyco-nanoparticles in a medium using a magneto-optical effect to determine transmission geometry.
A system for detecting a presence of pathogenic cells in a medium comprising:
- a device configured for mixing magnetic glyco-nanoparticles with the medium whereby a glyco-nanoparticle-pathogen complex is formed if any pathogenic cells are present in the medium;
- a device configured for separating the glyco-nanoparticle-pathogen complex from the medium;
- and,
- a device configured for measuring a response of the glyco-nanoparticle-pathogen complex.
An article using the glyco-nanoparticle-pathogen complex as in any of the preceding claims as an anti-infectious agent comprising:
- a device for mixing magnetic glyco-nanoparticles with at least one medium believed to contain cells of one or more pathogenic agents, whereby the magnetic glyco-nanoparticles attach to cells of the pathogenic agent;
- and,
- a device for separating the cells from the medium.
A magneto-plasmonic material comprising magnetic nanoparticles implanted, patterned or coated on a surface, the magnetic nanoparticles exhibiting modulated surface plasmon resonance properties.
A programmed computer system for detecting magnetic nanoparticles comprising:
- measuring a magneto-optical enhancement of a plasmon absorption optical response.
Dependencies are inferred from the claim text.