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US 2010/0160755 A1Published application
Polyelectrolytes as Sublayers on Electrochemical Sensors
AssigneeEdwards Lifesciences Corporation
InventorsHenry W. Oviatt, James R. Petisce
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Abstract
Disclosed herein is an electrochemical sensor for measuring an analyte in a subject. More particularly, sensors comprising a polyelectrolyte layer at least partially covering the electroactive surface of an electrode are disclosed.
Claims26
An electrochemical analyte sensor comprising:
- at least one non-reference electrode having an electroactive surface;
- and
- a polyelectrolyte layer covering at least a portion of the electroactive surface of the at least one non-reference electrode.
The electrochemical analyte sensor of claim 14, wherein the enzyme layer comprises glucose oxidase, poly-N-vinylpyrrolidone, and optionally an amount of crosslinking agent sufficient to immobilize the glucose oxidase.
An electrochemical analyte sensor assembly comprising:
- a flex circuit comprising at least one reference electrode and at least one working electrode, the at least one working electrode having an electroactive surface capable of providing a detectable electrical output upon interaction with an electrochemically detectable species;
- a polyelectrolyte layer at least partially covering the electroactive surface of the working electrode, wherein the polyelectrolyte layer comprises carboxylic acid functionality or sulfonate functionality;
- wherein the flex circuit is electrically configurable to a control unit capable of at least receiving the detectable electrical output.
Dependencies are inferred from the claim text.