In vitro fertilization

A method of in vitro fertilization wherein said method includes preimplantation genetic diagnosis of an IVF embryo comprising the steps of:

• a) biopsying said IVF embryo to remove one or more cells from said embryo;
• b) extracting nucleic acid from said one or more cells;
• c) performing whole-genome amplification of said nucleic acid;
• d) gathering genetic information for said IVF embryo comprising performing the following substeps (i) and (ii):
• i) determining the copy number of one or more SNPs for all 24 chromosomes in said IVF embryo;
• and
• ii) determining the copy number of all 24 chromosomes in said IVF embryo;
• and optionally
• iii) determining the presence of a loss or gain in chromosomal heterozygosity in said IVF embryo;
• e) predicting the genetic normalcy of the IVF embryo based on the genetic information obtained in (d) if the genetic information collected in (d)(i) indicates at least 90% SNP copy number concurrence, and the genetic information collected in (d)(ii) indicates at least a 50% chromosomal copy number concordance and where applicable, the genetic information collected in (d)(iii) indicates neither a gain nor loss of heterozygosity and
• (f) selecting one or more IVF embryos for transfer based on the determination made in step (e).