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AssigneesBexcore Co., Ltd., Daewon Pharm. Co., Ltd.
InventorsSeong-Wook Lee, Kyung-Sook Shin, Jong-Hoon Lim, Young-Joo Lee, Chang-Ho Lee
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Disclosed a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and inhibiting the proliferation of the HCV replicon, and is composed of at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2′-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 4, which is tagged with a cholesteryl group at a 5′ end and with idT at a 3′ end. The RNA aptamer is useful in the diagnosis and treatment of HCV infection.
A nuclease-resistant RNA aptamer, capable of binding specifically to hepatitis C virus (HCV) NS5B and inhibiting the proliferation of an HCV replicon, composed of at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2′-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 4, which is tagged with a cholesteryl group at a 5′ end and with idT at a 3′ end.
A kit for diagnosis of HCV, comprising at least one RNA aptamer selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2′-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 4, which is tagged with a cholesteryl group at a 5′ end and with idT at a 3′ end, whereby the specific binding of the RNA aptamer to HCV NS5B can be detected.
An inhibitor of hepatitis C virus, capable of binding specifically to hepatitis C virus (HCV) NS5B and inhibiting proliferation of an HCV replicon, comprising at least one RNA aptamer composed of at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2′-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 4, which is tagged with a cholesteryl group at a 5′ end and with idT at a 3′ end.
Dependencies are inferred from the claim text.