US 2010/0145070 A1 · ANTI-CANCER COMPOUND AND MANUFACTURING METHOD THEREOF

Abstract

Anti-cancer compounds and manufacturing methods thereof are disclosed. The anti-cancer compounds are 1,8-diamidoanthraquinone derivatives with amino compounds. The manufacturing method includes the steps of: add 1,8-bis(chloroacetamido)anthraquinone or 1,8-bis(3-chloropropionamido)-anthraquinone with amino compounds, catalysts, and dehydrated dimethylformamide (DMF) to form a mixture and react with one another. Then by purification and recrystallization, the anti-cancer compounds are obtained. The anti-cancer compounds of the present invention are compounds with whole new structure that overcome serious cardiac toxicity of the conventional anti-cancer drug-doxorubincin.

Claims18

Dependent claims

A series of anti-cancer compounds comprising:

wherein n=1 and R is NHCH2CO2CH3,
NHCH(CH2CH2SCH3)CO2CH3,
N(CH2CH2CH2CH2)CO2CH3, NHCH(CH(CH3)2)CO2CH3, (D)-NHCH(CH(CH3)2)CO2CH3, N(CH3)CH2CO2CH3, NHCH(CH2CH(CH3)2)CO2CH3, NHCH(CH3)CO2CH3, (D)-NHCH(CH3)CO2CH3, NHCH(C6H5)CO2CH3, NHCH2CH(CH3)2, N(CH2CH3)2, N(CH3)2, N(CH2CH2CH3)2, NHCH(CH3)2, NHCH2CH3, 3-(CF3)C6H4—CH2NH, N(CH3)CH2CH3, N(CH3)CH2CH2CH3 NHCH(CH2OCH(CH3)3)CO2CH3 . . .
wherein n=2 and R is N(CH2CH3)2, NHCH2CH(CH3)2, 3,5-F2C6H3CH2NH, NHCH2CH2NHCO2C(CH3), NHCH2CH2N(CH3)2, N(CH3)2, N(CH2CH2CH3)2, NHCH3—NHCH(CH3)2, NHCH2CH2CH2N(CH3)2, or N(CH3)CH2CH3.

1 more element

Dependencies are inferred from the claim text.

Anti-cancer compound and manufacturing method thereof

Life of this patent

Anti-cancer compound and manufacturing method thereof

Life of this patent

Abstract

Claims18