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US 2010/0145049 A1Published application
Process for making n-(diphenylmethyl)piperazines
OwnerJie Zhu, Judith Janneke Firetinventors
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Abstract
A compound of formula (8) or a salt thereof: wherein Z represents a group containing 1-20 carbon atoms and at least one chiral carbon atom and having a single conformation, is useful in the synthesis of pharmaceutical compounds, especially chiral compounds such as levocetirizine.
Claims19
A compound of formula (8) or a salt thereof:
- wherein Z represents a group containing 1-20 carbon atoms and at least one chiral carbon atom and having a single conformation.
A process, which comprises:
- (a) providing a pair of diastereomers of the formula (8) or a salt thereof:
- wherein Z represents a group containing 1-20 carbon atoms and at least one chiral carbon atom and having a single conformation;
- (b) resolving said diastereomers of formula (8) to obtain the single diastereomer having the chiral methyl group in the R-conformation;
- and
- (c) hydrolyzing the single diastereomer of the compound (8) having the chiral methyl group in the R-conformation to form the (R)-enantiomer of the compound (4)
- or a salt thereof.
3 more elements
Dependencies are inferred from the claim text.