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US 2010/0145007 A1Published application
Chimeric peptide antagonist for gpcr135 or gpcr142
AssigneeJanssen Pharmaceutica NV
InventorsChester Kuei, Changlu Liu, Cindy M. Pudiak, Jonathan Shelton, Steven W. Sutton
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Abstract
The chimeric polypeptide R3(BΔ23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.
Claims3
A polypeptide comprising:
- a B-chain having the amino acid sequence RAAPYGVRLCGREFIRAVIFTCR (SEQ ID NO:
- 15);
- and
- an A-chain having the amino acid sequence <EDLQTLCCTDGCSMTDLSALC (SEQ ID NO:
- 19) or DVLAGLSSSCCKWGCSKSEISSLC (SEQ ID NO:
- 13).
3 more elements
Dependencies are inferred from the claim text.