Methods of diagnosis and treatment of crohn's disease
AssigneeCedars-Sinai Medical Center
InventorsKent D. Taylor, Jerome I. Rotter, Stephan R. Targan
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Abstract
In one embodiment, this invention provides methods of diagnosing and/or predicting susceptibility to Crohn's Disease by determining the presence or absence of risk haplotypes in IL23R, IL17A, IL17RA and/or IL12RB1 locus. In another embodiment, the invention provides methods of diagnosing and/or predicting susceptibility to Crohn's Disease in an individual by determining the presence or absence of risk haplotype at the IL12RB2 locus.
Claims22
A method of diagnosing susceptibility to Crohn's Disease in an individual, comprising:
- determining the presence or absence of a first risk haplotype at the IL23R locus, the presence or absence of a second risk haplotype at the IL17A locus, the presence or absence of a third risk haplotype at the IL17RA locus, and the presence or absence of a fourth risk haplotype at the IL12RB1 locus,
- wherein the presence of four of said risk haplotypes presents a greater susceptibility than the presence of three, two, one or none of said risk haplotypes, and the presence of three risk haplotypes presents a greater susceptibility than the presence of two, one or none of said risk haplotypes, and the presence of two risk haplotypes presents a greater susceptibility than the presence of one or none of said risk haplotypes, and the presence of one of said risk haplotypes presents a greater susceptibility than the presence of none of said risk haplotypes.
A method of treating Crohn's Disease, comprising:
- determining the presence of one or more risk haplotypes at the IL12RB1 locus;
- and
- treating the Crohn's Disease.
A method of determining a low probability relative to a healthy subject of developing Crohn's Disease, comprising:
- determining the presence or absence of a protective haplotype at the IL12RB2 locus in the individual;
- and
- diagnosing a low probability of developing Crohn's Disease, relative to a healthy subject, based upon the presence of the protective haplotype at the IL12RB2 locus.
A method of diagnosing susceptibility to Crohn's Disease in an individual, comprising:
- determining the presence or absence of one or more risk haplotypes at the IL12RB2 locus in the individual;
- and
- diagnosing susceptibility to Crohn's Disease based upon the presence of one or more risk haplotypes at the IL12RB2 locus.
A method of treating Crohn's Disease, comprising:
- determining the presence of one or more risk haplotypes at the IL12RB2 locus;
- and
- treating the Crohn's Disease.
Dependencies are inferred from the claim text.