Quinolines and Their Therapeutic Use

A compound of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 is halogen or cyano;
• R2 is hydrogen or methyl;
• R3 and R4 are independently —OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms;
• R5 is hydrogen or halogen;
• R6 is C1-C6alkyl or C3-C6cycloalkyl, either of which being optionally substituted by one or more halogen atoms;
• X is —CH2—, —S—, or —O—;
• one of Y and Y1 is hydrogen and the other is OR6;
• —C(═O)R7;
• NR8SO2R6 or a heterocyclic group selected from furan;
• thiophene;
• pyrrole;
• oxazole;
• thiazole;
• imidazole;
• pyrazole;
• isoxazole:
• isothiazole;
• 1,2,3-oxadiazole;
• 1,2,4-oxadiazole;
• 1,3,4-oxadiazole;
• furazan;
• 1,2,3-triazole;
• 1,2,4-triazole;
• 1,2,3-thiadiazole;
• 1,2,5-thiadiazole;
• 1,3,4-thiadiazole;
• tetrazole;
• pyridine:
• pyridazine;
• pyrimidine;
• pyrazine;
• 1,2,4-triazine;
• and 1,3,5-triazine,
• any of which may be optionally substituted by one or more substituents selected from halogen;
• cyano;
• C1-C6alkyl optionally substituted by one or more halogen atoms;
• C3-C6cycloalkyl optionally substituted by one or more halogen atoms;
• hydroxy;
• C1-C6alkoxy optionally substituted by one or more halogen atoms;
• C1-C6alkyl-O—CH2—;
• C1-C6alkyl-O—CH(RX)— and C1-C6alkyl-O—C(RXRY)— in which the C1-C6alkyl part is optionally substituted by one or more halogen atoms;
• NH2C(═O)—;
• RXNHC(═O)—;
• RXRYNC
• (═O)—;
• RXRYNS(═O)2—;
• RXNHS(═O)2—;
• NH2S(═O)2—;
• NH2—;
• RXNH—;
• RXRYN—;
• RXS(═O)2—;
• RXC(═O)—;
• RXS(═O)2NH—;
• RXS(═O)2NRY—;
• RXC(═O)NH— and RXC(═O)N(RY)—;
• wherein RX and RY are independently C1-C4alkyl or C3-C6cycloalkyl, either of which being optionally substituted by one or more halogen atoms;
• or RX and RY when attached to the same nitrogen atom form a cyclic amino ring;
• R7 is C1-C6alkyl or C3-C6cycloalkyl either of which being optionally substituted by one or more halogen atoms;
• or phenyl or monocyclic heteroaryl having 5 or 6 ring atoms, optionally substituted by one or more substituents independently selected from halogen;
• cyano;
• C1-C6alkyl optionally substituted by one or more halogen atoms;
• C3-C6 cycloalkyl optionally substituted by one or more halogen atoms;
• hydroxy;
• C1-C6alkoxy optionally substituted by one or more halogen atoms;
• C1-C6alkyl-O—C2—;
• C1-C6alkyl-O—CH(RX)— and C1-C6alkyl-O—C(RXRY)— in which the C1-C6alkyl part is optionally substituted by one or more halogen atoms;
• NH2C(═O)—;
• RXNHC(═O)—;
• RXRYNC(═O)—;
• RXRYNS(═O)2—;
• RXNHS(═O)2—;
• NH2S(═O)2—;
• NH2—;
• RXNH—;
• RXRYN—;
• RXS(═O)2—;
• RXC(═O)—;
• RXS(═O)2NH—;
• RXS(═O)2NRY—;
• RXC(═O)NH— and RXC(═O)N(RY)—;
• wherein RXRY are independently C1-C4alkyl or C3-C6cycloalkyl, either of which being optionally substituted by one or more halogen atoms;
• or RX and RY when attached to the same nitrogen atom form a cyclic amino ring;
• and
• R8 is hydrogen, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms.