Antimicrobial Molecules For Treating Multi-Drug Resistant And Extensively Drug Resistant Strains Of Mycobacterium
AssigneePolymedix, Inc.
InventorsRichard W. Scott, Dahui Liu
Life of this patent
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Abstract
The present invention provides methods of inhibiting the growth of Mycobacterium species or treating an animal having a Mycobacterium infection (including multi-drug resistance strains and extensively drug resistant strains) by administering a compound of the invention, a salt thereof, or a composition comprising the same.
Claims30
A method of inhibiting the growth of a Mycobacterium species comprising contacting the Mycobacterium species with an effective amount of a compound or salt thereof, wherein the compound or salt thereof is selected from:
- a) a compound of Formula I:
- or salt thereof, wherein R1 is H or C1-10 alkyl;
- R2 is H or C1-10 alkyl;
- and m is 1 or 2;
- b) a compound of Formula II:
- or salt thereof, wherein R3 is H or C1-10 alkyl;
- and R4 is H or C1-10 alkyl;
- and
- c) a compound of Formula III:
- or salt thereof, wherein R5 is H or C1-10 alkyl;
- and R6 is H or C1-10 alkyl.
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A method of treating an animal having a Mycobacterium infection comprising administering to the animal a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, wherein the compound or pharmaceutically acceptable salt thereof is selected from:
- a) a compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein R1 is H or C1-10 alkyl;
- R2 is H or C1-10 alkyl;
- and m is 1 or 2;
- b) a compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein R3 is H or C1-10 alkyl;
- and R4 is H or C1-10 alkyl;
- and
- c) a compound of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein R5 is H or C1-10 alkyl;
- and R6 is H or C1-10 alkyl.
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Dependencies are inferred from the claim text.