Inhibitors of human tumor-expressed ccxckr2

A modulator of the structure (I), or a salt thereof:

• where m is an integer from 1 to 5;
• each Y is independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, —OH, —OR′, —C(O)R′, —CO2R′, —O(CO)R′, —C(O)NR′R″, —OC(O)NR′R″, —SR′, —SOR′, —SO2R′, —SO2NR′R″, —NR′R″, —NR′C(O)R″, —NR′C(O)2R′, —NR′SO2R″, —NR′(CO)NR″R″, unsubstituted or substituted C1-8 alkyl, unsubstituted or substituted C2-8 alkenyl, unsubstituted or substituted C2-8 alkynyl, unsubstituted or substituted C3-8 cycloalkyl, unsubstituted or substituted C6-10 aryl, unsubstituted or substituted 5- to 10-membered heteroaryl, and unsubstituted or substituted 3- to 10-membered heterocyclyl;
• where each R′, R″ and R′″ are independently hydrogen, halogen, unsubstituted or substituted C1-8 alkyl, unsubstituted or substituted C6-10 aryl, unsubstituted or substituted 5- to 10-membered heteroaryl, and unsubstituted or substituted 3- to 10-membered heterocyclyl;
• n is 0, 1, 2 or 3;
• Z is —CHR1R2—, —OR1, or —NR1R2;
• R1 and R2 are each independently substituted or unsubstituted alkyl or hydrogen, or Z in combination with R1 and R2 form a substituted or unsubstituted 5- to 8-membered ring comprising at least one nitrogen and 0 to 3 additional heteroatoms;
• R6 is alkyl, hydrogen, or halogen;
• and
• R3, R4, and R5 are each independently selected from the group consisting of hydrogen, halogen, —CN, —NO2, —OH, —OR′, —C(O)R′, —CO2R′, —O(CO)R′, —C(O)NR′R″, —OC(O)NR′R″, —SR′, —SOR′, —SO2R′, —SO2NR′R″, —NR′R″, —NR′C(O)R″, —NR′C(O)2R″, —NR′SO2R″, —NR′(CO)NR″R′″, unsubstituted or substituted C1-8 alkyl, unsubstituted or substituted C2-8 alkenyl, unsubstituted or substituted C2-8 alkynyl, unsubstituted or substituted C3-8 cycloalkyl, unsubstituted or substituted C6-10 aryl, unsubstituted or substituted 5- to 10-membered heteroaryl, and unsubstituted or substituted 3- to 10-membered heterocyclyl, or where any two of R3, R4 or R5 together with the atoms which they substituted form a substituted or unsubstituted 3- to 10-membered heterocycyl.