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US 2010/0144719 A1Published application
Pharmaceutical suspension
AssigneeAlcon Research, Ltd.
InventorBhagwati P. Kabra
Life of this patent
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Abstract
The present invention is directed to the provision of a pharmaceutical suspension. The suspension includes high molecular weight polyethylene glycol as a suspending agent. The suspension also typically includes an antimicrobial agent (e.g., polymeric quaternary ammonium compound), an antimicrobial system (e.g., borate/polyol complex system) or both. The suspension has been found particularly useful as an ophthalmic suspension, but can be used in other instances as well.
Claims23
A pharmaceutical suspension, comprising:
- an aqueous solution that includes high molecular weight polyethylene glycol, polyethylene oxide or both as a suspending agent, the high molecular weight polyethylene glycol, when included, having a molecular weight that is at least 2000;
- and
- a therapeutic agent that is suspended or suspendable within the solution.
A pharmaceutical suspension, comprising:
- an aqueous solution that includes high molecular weight polyethylene glycol, polyethylene oxide or both as a suspending agent, the high molecular weight polyethylene glycol, when included, having a molecular weight that is at least 2000;
- and
- therapeutic agent that is suspended or suspendable within the solution;
- wherein the suspension has a degree of flocculation of at least 10;
- wherein the suspension is an ophthalmic, otic or nasal suspension;
- wherein the viscosity of the suspension is greater than 15 cps but no greater than 1000 cps wherein the viscosity of the suspension is measured at a high shear rate of 46 sec−1 at room temperature.
3 more elements
Dependencies are inferred from the claim text.