Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers

A compound represented by formula (I):

• and pharmaceutically acceptable salts thereof, wherein
• each R1 is independently selected from the group consisting of hydrogen,
• halogen,
• cyano,
• C1-6 alkyl, unsubstituted or substituted with one to five halogens, and
• C1-6 alkoxy, unsubstituted or substituted with one to five halogens;
• R2 is independently selected from the group consisting of
• hydrogen,
• C1-6 alkyl, unsubstituted or substituted with one to six substituents selected from halogen and hydroxy,
• C1-6 alkenyl,
• C1-6 alkynyl,
• C1-6 alkoxy-C1-6 alkylene, unsubstituted or substituted with one to six halogens,
• C1-6 cycloalkyl, wherein cycloalkyl is unsubstituted or substituted with one to six substituents independently selected from halogen, cyano, C1-6 alkyl and
• C1-6 alkoxy, wherein alkyl and alkoxyl are unsubstituted or substituted with one to six halogens, and
• C1-6 cycloalkyl-C1-6alkylene, wherein cycloalkyl is unsubstituted or substituted with one to six substituents independently selected from halogen, cyano, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxyl are unsubstituted or substituted with one to six halogens;
• R3 is independently selected from the group consisting of
• hydrogen and
• C1-6 alkyl;
• R4 is independently selected from the group consisting of
• C1-10 alkyl, unsubstituted or substituted with one to six halogens,
• C1-10 alkoxy, unsubstituted or substituted with one to six halogens,
• C1-10 cycloalkyl-C0-6 alkylene, wherein cycloalkyl is unsubstituted or substituted with one to six substituents independently selected from halogen, cyano, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxyl are unsubstituted or substituted with one to six halogens,
• —(CH2)m-aryl wherein m is 0, 1, 2 or 3, and wherein aryl is unsubstituted or substituted with one to five substituents independently selected from halogen, cyano, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to six halogens, and
• —(CH2)m-heteroaryl wherein m is 0, 1, 2 or 3, and wherein heteroaryl is unsubstituted or substituted with one to five substituents independently selected from halogen, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to six halogens;
• R5 is independently selected from the group consisting of
• —(CH2)n-aryl wherein n is 0, 1, or 2, and wherein aryl is unsubstituted or substituted with one to five substituents independently selected from hydroxy, halogen, cyano, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to six halogens,
• —(CH2)n-heteroaryl wherein n is 0, 1 or 2, and wherein aryl is unsubstituted or substituted with one to five substituents independently selected from halogen, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to six halogens;
• X is independently selected from the group consisting of
• oxygen,
• nitrogen, unsubstituted or substituted with one R6 as defined herein,
• sulfur,
• sulfoxide, and
• sulfone;
• R6 is independently selected from the group consisting of
• C1-10 alkyl, unsubstituted or substituted with one to six halogens,
• C1-10 alkoxy, unsubstituted or substituted with one to six halogens,
• C1-10 cycloalkyl-C0-6 alkylene, wherein cycloalkyl is unsubstituted or substituted with one to six substituents independently selected from halogen, cyano, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxyl are unsubstituted or substituted with one to six halogens,
• —(CH2)p-aryl wherein p is 0, 1, 2 or 3, and wherein aryl is unsubstituted or substituted with one to five substituents independently selected from halogen, cyano, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to six halogens, and
• —(CH2)p-heteroaryl wherein p is 0, 1, 2 or 3, and wherein heteroaryl is unsubstituted or substituted with one to five substituents independently selected from halogen, C1-6 alkyl and C1-6 alkoxy, wherein alkyl and alkoxy are unsubstituted or substituted with one to six halogens.