Triazole derivatives having antifungal activity, method for the preparation thereof, and pharmaceutical composition comprising the same

A compound of formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof:

• wherein,
• n is 1 or 2;
• A is a direct bond, C═O or CH2;
• R is a 5 to 10-membered mono- or bi-cyclic heteroaryl ring containing 1 to 4 atoms each independently selected from the group consisting of N, O and S in its ring structure, which is substituted with one or more substituents each independently selected from the group consisting of hydrogen, halogen, hydroxy, cyano, nitro, amino, hydroxycarbonyl, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6alkoxy, hydroxyl C1-6alkyl, C1-6alkoxy C1-6alkyl, perfluoro C1-6alkyl, perfluoro C1-6alkoxy, C1-6alkylamino, diC1-6alkylamino, aminoC1-6alkyl, C1-6alkylamino C1-6alkyl, diC1-6alkylamino C1-6alkyl, C1-6acyl, C1-6acyloxy, C1-6acyloxyC1-6alkyl, C1-6acylamino, C1-6alkylthio, C1-6alkylthiocarbonyl, C1-6alkylthioxo, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfonylamino, aminosulfonyl, C1-6alkylaminosulfonyl, diC1-6alkylaminosulfonyl, 3- to 8-membered cycloalkyl, 3- to 8-membered cycloalkoxy, 3- to 8-membered cycloalkyl-C1-6alkoxy, 3- to 8-membered cycloalkyl-C1-6alkylamino, N—C1-6alkyl N-3- to 8-membered cycloalkyl-C1-6alkylamino, 4- to 8-membered heterocycloalkyl, 4- to 8-membered heterocycloalkyl-C1-6alkoxy, 4- to 8-membered heterocycloalkyl-C1-6alkylamino, N—C1-6alkyl N-4- to 8-membered heterocycloalkyl-C1-6alkylamino, heteroaryl-C1-6alkyl, heteroaryl-C1-6alkoxyl, heteroaryl-C1-6alkylamino, N—C1-6alkyl N-heteroaryl-C1-6alkylamino, phenyl and monocyclic heteroaryl.