Compositions, methods and uses for inhibition and/or treatment of influenza infection
OwnerLeland Shapiroinventor
Life of this patent
Estimating the term…
Abstract
Embodiments of the present invention illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing or inhibiting onset, transmission or development of a viral disorder.
Claims20
A method for modulating shedding of a virus in a subject infected with the virus comprising, administering to the subject having a viral infection a therapeutically effective amount of a composition comprising one or more peptides derived from the carboxyterminal 80 amino acids of SEQ ID NO:20 corresponding to amino acid 315 and ending at amino acid 394, wherein the composition modulates shedding of the virus.
The method of claim 6, wherein the composition comprises FVFLM (SEQUENCE ID NO. 1) or analog thereof, FVYLI (SEQUENCE ID NO. 16), LEAIPMSIPPEVKFNKPFVFLM (SEQ ID NO:
- 36);
- and LEAIPMSIPPEVKFNKPFVF (SEQ ID NO:
- 37) or a mixture thereof.
A method for modulating shedding of a virus in a subject infected with the virus comprising, administering to the subject having a viral infection a therapeutically effective amount of a composition comprising SEQ ID NO:20, wherein the composition modulates shedding of the virus.
A composition for modulating shedding of a virus in a subject infected with the virus comprising, one or more peptides derived from the carboxyterminal 80 amino acids of SEQ ID NO:20 beginning at amino acid 315 and ending at amino acid 394, the composition modulates shedding of the virus from a cell.
A kit for modulating shedding of a virus comprising:
- at least one container;
- and
- at least one composition comprising one or more of FVFLM (SEQUENCE ID NO. 1), an analog of FVFLM comprising FVYLI (SEQUENCE ID NO. 16), GADLSGVTEE (SEQ ID NO:21);
- KAVLTIDEKG (SEQ ID NO:22);
- TEAAGAMFLE (SEQ ID NO:23);
- RIPVSIPPEV (SEQ ID NO:24);
- KFNKPFVFLM (SEQ ID NO:25);
- IEQNTKSPLF (SEQ ID NO:26);
- MGKVVNPTQK (SEQ ID NO:27);
- LSGVTEEAPL (SEQ. ID NO. 28);
- KLSKAVHKAV (SEQ. ID NO. 29);
- LTIDEKGTEA (SEQ. ID NO. 30);
- AGAMFLERIP (SEQ. ID NO. 31);
- VSIPPEVKFN (SEQ. ID NO. 32);
- KPFVFLMIEQ (SEQ. ID NO. 33);
- NTKSPLFMGK (SEQ. ID NO. 34);
- VVNPTQK (SEQ. ID NO. 35);
- LEAIPMSIPPEVKFNKPFVFLM (SEQ ID NO:
- 36);
- LEAIPMSIPPEVKFNKPFVF (SEQ ID NO:
- 37) or a mixture thereof.
A method for modulating influenza infection of cells of a subject comprising, administering to the subject having an influenza infection a therapeutically effective amount of a composition comprising SEQ ID NO:20 or one or more peptides derived from the carboxyterminal 80 amino acids of SEQ ID NO:20 corresponding to amino acid 315 and ending at amino acid 394, modulating hemagluttinin processing of influenza wherein modulating hemagluttinin processing of influenza reduces infectivity of influenza.
Dependencies are inferred from the claim text.