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AssigneeGarvan Institute of Medical Research
InventorsHerbert Herzog, Charles Mackay
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The present invention provides transgenic animals having a reduced level of expression of peptide YY (PYY) and drug screening platforms using the transgenic animals for identifying agonists and antagonists of PYY. The present invention further provides monoclonal antibodies that bind specifically to full-length PYY[1-36] or the processed form thereof i.e., PYY[3-36] and to diagnostic and drug screening platforms using the monoclonal antibodies. The invention has particular utility for the diagnosis of a predisposition or risk of a subject becoming obese, developing one or more pathologies associated with obesity, or developing a disease/disorder of bone tissue.
A genetically modified non-human animal in which the expression of precursor peptide YY (PYY) or a derivative thereof is reduced or prevented by targeted disruption of an endogenous PYY-encoding gene.
An isolated antibody that binds specifically to human PYY[1-36] or a fragment thereof comprising the N-terminal two or three amino acid residues thereof or that binds specifically to a human PYY[3-36] or a fragment thereof comprising residues from position 3 to position 13 of human PYY[1-36].
Dependencies are inferred from the claim text.