Peptide compounds for capturing or inhibiting avian influenza virus and application thereof
AssigneeElectronics and Telecommunications Research Institute
InventorsHyobong HONG, Soohyung Lee, Taewan Kim, Myungae Chung, Sungwon Shon
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Abstract
Disclosed herein are peptide, particularly dipeptide compounds and the application thereof to the detection or inhibition of AI virus. The peptide compounds are more stable and easier to synthesize and store than are antibodies. In addition, having strong binding forces for the H5 protein of AI virus, the peptide compounds are useful as capturers or inhibitors of AI virus.
Claims13
An agent for capturing or inhibiting avian influenza virus, comprising as an active ingredient a compound represented by the following Chemical Formula 1:
- wherein
- X and X′ are independently:
- H;
- a functional group selected from the group consisting of biotin, streptavidin and avidin;
- or a functional moiety composed of a functional group selected from the group consisting of biotin, streptavidin and avidin, and a linker which connects the functional group to a backbone of the compound of Chemical Formula 1 therethrough;
- m is an integer of 2˜10;
- n is 0 or 1;
- and
- R is selected from the group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CHCH3CH2CH3, —CH2OH, —CHOHCH3, —CH2SH, —(CH2)2SCH3, —CH2COOH, —CH2CONH2, —(CH2)2COOH, —(CH2)2CONH2, —(CH2)3CH2NH2, —(CH2)3NHCNHNH2,
- —CH2CH2CH2— and —CH2SSCH2—.
A compound for capturing or inhibiting avian influenza virus, represented by the following Chemical Formula 1:
- wherein
- X and X′ are independently H;
- a functional group selected from the group consisting of biotin, streptavidin and avidin;
- or a functional moiety composed of a functional group selected from the group consisting of biotin, streptavidin and avidin, and a linker which connects the functional group to the backbone of the compound of Chemical Formula 1 therethrough, with a proviso that X and X′ are not H at the same time;
- m is an integer of 2˜10;
- n is 0 or 1;
- and
- R is selected from the group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CHCH3CH2CH3, —CH2OH, —CHOHCH3, —CH2SH, —(CH2)2SCH3, —CH2COOH, —CH2CONH2, —(CH2)2COOH, —(CH2)2CONH2, —(CH2)3CH2NH2, —(CH2)3NHCNHNH2,
- —CH2CH2CH2— and —CH2SSCH2—.
A method for detecting avian influenza virus, comprising contacting a compound, represented by the following Chemical Formula 1, with a sample to be tested:
- wherein
- X and X′ are independently:
- H;
- a functional group selected from the group consisting of biotin, streptavidin and avidin;
- or a functional moiety composed of a functional group selected from the group consisting of biotin, streptavidin and avidin, and a linker which connects the functional group to a backbone of the compound of Chemical Formula 1 therethrough;
- m is an integer of 2˜10;
- n is 0 or 1;
- and
- R is selected from the group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CHCH3CH2CH3, —CH2OH, —CHOHCH3, —CH2SH, —(CH2)2SCH3, —CH2COOH, —CH2CONH2, —(CH2)2CONH2, —(CH2)3CH2NH2, —(CH2)3NHCNHNH2,
- —CH2CH2CH2— and —CH2SSCH2—.
Dependencies are inferred from the claim text.