Polyphenol containing compositions

A method for loading a polyphenol or polyphenol derivative having a deprotonatable hydroxyl group into long-circulating colloid carriers, said method comprising:

• (a) preparing a suspension of long-circulating liposomes, having a greater concentration of metal cations inside the liposomes than outside the liposomes, said metal cations being capable of forming complexes or precipitates at relatively high pH with the negatively charged polyphenol or polyphenol derivatives,
• (b) adding polyphenol or polyphenol derivative compounds to the said suspension, and
• (c) achieving uptake of the compound into the liposomes, to a final concentration of compound within the liposomes which is greater than that outside the liposomes.