Methods of enhancing protein incorporation into virus like particles
OwnerGale SMITH, Peter Pushkoinventors
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Abstract
The present invention comprises a method of increasing glycoprotein incorporation on the surface of VLPs, comprising expressing a nucleic acid encoding a chimeric glycoprotein in a host cell, wherein said chimeric glycoprotein comprises the transmembrane domain of an influenza hemagglutinin protein. The invention also embodies specific VLPs comprising said chimeric glycoproteins and methods of inducing immunity in an animal utilizing said VLPs.
Claims29
A method of increasing the incorporation of a viral glycoprotein on the surface of a virus-like particle (VLP), comprising expressing a nucleic acid encoding a chimeric glycoprotein in a host cell with a non-influenza viral core, wherein said chimeric glycoprotein comprises the transmembrane domain of an influenza hemagglutinin protein and at least a portion of a viral protein derived from a non-influenza source.
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A virus like particle (VLP) comprising at least one chimeric glycoprotein on the surface of the VLP and a non-influenza viral core, wherein said chimeric glycoprotein comprises the transmembrane domain of an influenza hemagglutinin protein and at least a portion of a viral protein derived from a non-influenza source.
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23-25. (canceled)
27-28. (canceled)
A method of inducing protective immunity in an animal, comprising administering to said animal a VLP comprising at least one chimeric glycoprotein on the surface of the VLP and a non-influenza viral core, wherein said chimeric glycoprotein comprises the transmembrane domain of an influenza hemagglutinin protein and at least a portion of a viral protein derived from a non-influenza source.
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32-37. (canceled)
Dependencies are inferred from the claim text.