Methods for the treatment of a-beta related disorders and compositions therefor
AssigneeThe Rockefeller University
InventorsMarc Flajolet, Paul Greengard
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Abstract
The invention provides methods for treating Aβ peptide related disorders such as Alzheimer's disease comprising administering a therapeutically effective amount of a CK1 modulator to a patient in need thereof.
Claims28
A method of treating an Aβ related disorder comprising administering to a subject in need thereof an amount of a CK1 modulator effective to inhibit or reduce accumulation of Aβ peptide.
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A method to identify modulators useful to treat Aβ related disorders through reduction of the accumulation of Aβ peptide, comprising assaying for the ability of a candidate modulator to inhibit CK1 activity.
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A method of diagnosis for an Aβ related disorder comprising detecting mRNA levels and/or protein levels of CK1 in a biological sample wherein elevated levels of CK1 compared to normal levels indicate the presence or enhanced risk of Aβ disorders.
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Dependencies are inferred from the claim text.