Methods and compositions for treating cancer
AssigneeSchering Corporation
InventorsParag Kolhe, Vinay Radhakrishnan, Leonore Witchey-Lakshmanan
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for preventing or treating a medical disorder in a subject comprising administering to the subject an effective amount of a stable pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof.
Claims25
A method for treating or preventing a medical condition mediated by expression or activity of IGF1R comprising administering a dosage of an antibody or antigen-binding fragment thereof which binds specifically to IGF1R which dosage amount and frequency achieves and maintains a blood concentration of at least about 19 μg/mL.
A unit dosage form comprising one or more doses of a pharmaceutically acceptable carrier and an antibody or antigen-binding fragment thereof comprising one or more members selected from the group consisting of:
- (a) CDR-L1, CDR-L2 and CDR-L3 of the variable region of the 19D12/15H12 light chain immunoglobulin, and
- (b) CDR-H1, CDR-H2 and CDR-H3 of the variable region of the 19D12/15H12 heavy chain immunoglobulin;
- wherein said dose is sufficient to reach and maintain a 19 μg/mL blood concentration of said antibody or fragment when administered once every three weeks or more frequently.
Dependencies are inferred from the claim text.