Akt nucleic acids, polypeptides, and uses thereof
AssigneeAventis Pharmaceuticals Inc.
InventorsKun GUO, Marco F. PAGNONI, Kenneth L. CLARK, Yuri D. IVASHCHENKO
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Abstract
The present invention relates to human Akt3 proteins and polypeptides. The invention also relates to isolated nucleic acids encoding human Akt3, to vectors containing them and to their therapeutic uses, in particular for gene therapy. Expression of Akt3 inhibits cell death associated with hypoxia, apoptosis or necrosis.
Claims26
An isolated human Akt3 protein comprising the sequence Cys-Gln-Gln-Ser-Asp-Cys-Gly-Met-Leu-Gly-Asn-Trp-Lys-Lys, or a substantially similar sequence, wherein the protein has a property selected from the following:
- A. it is encoded by a nucleic acid comprising SEQ ID NO:1;
- B. it comprises an amino acid sequence as depicted in SEQ ID NO:2, splice variants thereof, or allelic variants thereof;
- and
- C. it specifically binds to an antibody generated against an epitope within a peptide having the sequence Cys-Gln-Gln-Ser-Asp-Cys-Gly-Met-Leu-Gly-Asn-Trp-Lys-Lys, or a substantially similar sequence.
A method of treating myocardial infarction or ischemia reperfusion injury, the method comprising administering to a patient suffering therefrom a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1 or a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the nucleic acid is operably linked to a regulatory region.
Dependencies are inferred from the claim text.