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OwnerIan Walter Kellaway, Kevin Taylor +1inventors
InventorsIan Walter Kellaway, Kevin Taylor, Bildad Kimani Nyambura
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A formulation suitable for delivery from a pressurised metered dose inhaler comprises a hydrofluoroalkane liquid, which is pharmaceutically acceptable, for instance HFA 134a or HFA 227, a drug to be delivered to the lung which is insoluble in the hydrofluoroalkane, the drug being in particulate form in the composition, further containing a suspension stabiliser which is a non-toxic essential oil miscible with the hydrofluoroalkane liquid at room temperature. The essential oil is preferably one having some amphiphilic property, such as a ketone or aldehyde compound. Insulin may be formulated for inhalation.
A pressurised metered dose inhaler comprising a composition comprising a pharmaceutically acceptable hydrofluoroalkane liquid propellant, a drug to be delivered to the lung which is insoluble in the hydrofluoroalkane liquid, in particulate form, and a suspension stabiliser which is a pharmaceutically acceptable essential oil which is miscible with the hydrofluoroalkane liquid at room temperature.
(canceled)
A use of a pharmaceutically acceptable essential oil to stabilise in an MDI a suspension of a particulate drug in a pharmaceutically acceptable hydrofluoroalkane liquid in which the drug is insoluble and with which the essential oil is miscible.
A use of a combination of a pharmaceutically acceptable hydrofluoroalkane liquid, a drug and a pharmaceutically acceptable essential oil in the manufacture of a composition for administration to the lung of an animal subject via inhalation, wherein the drug is in particulate form in the composition, the particles of drug are suspended in the hydrofluoroalkane liquid, the essential oil is miscible with the hydrofluoroalkane and the suspension is stabilised by the essential oil.
(canceled)
A pressurised composition for inhalation comprising a pharmaceutically acceptable hydrofluoroalkane liquid propellant, insulin in suspended particulate form and cineole.
A pressurised composition inhalation for comprising a pharmaceutically acceptable hydrofluoroalkane liquid propellant, a steroid or corticosteroid for delivery to the lung and citral.
Dependencies are inferred from the claim text.