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US 2010/0137676 A1Published application
N-acetylcysteine amide (nac amide) for treatment of oxidative stress associated with infertility
OwnerGlenn A. Goldsteininventor
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OwnerGlenn A. Goldsteininventor
Estimating the term…
An in vitro culture and/or fertilization medium containing N-acetylcysteine amide (NAC amide) reduces or prevents oxidative stress and free radical formation that contribute to the cellular damage and eventual demise of sperm, oocytes and embryos that are cultured, fertilized and maintained in vitro. The NAC amide-containing medium composition for in vitro culture and fertilization is suitable for use in the culture of oocytes, in the culture and development of early embryos, in the preparation or culture of sperm, and in the pre-treatment of oocytes or sperm. The NAC amide-containing composition supports the growth of viable embryos until blastocyst stage.
-20. (canceled)
A method of in vitro fertilization, comprising cultivating oocytes and sperm in a medium supplemented to contain N-acetylcysteine amide (NAC amide), or a physiologically acceptable salt or ester thereof, wherein said oocytes are fertilized by said sperm in said NAC amide-supplemented medium.
-33. (canceled)
A cell culture medium for reducing or preventing oxidative stress in oocytes, sperm, or embryos cultured in vitro, comprising N-acetylcysteine amide (NAC amide), or a physiologically acceptable salt or ester thereof.
A cell culture supplement for reducing or preventing oxidative stress in oocytes, sperm, or embryos cultured in vitro, comprising N-acetylcysteine amide (NAC amide), or a physiologically acceptable salt or ester thereof.
-56. (canceled)
Dependencies are inferred from the claim text.