N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application

A compound of the formula (I):

• in which:
• X represents a group
• R1 represents:
• a (C6-C12)alkyl;
• a nonaromatic (C3-C12) carbocyclic radical which is unsubstituted or substituted once or several times with a (C1-C4)alkyl;
• a methyl which is substituted with a nonaromatic C3-C12 carbocyclic radical and which is unsubstituted or substituted once or several times on the carbocycle with a (C1-C4)alkyl;
• a phenyl which is mono-, di- or -trisubstituted with substituents independently chosen from a halogen atom, a (C1-C4)alkoxy, a (C1-C4)alkylamino, a di-(C1-C4)alkylamino, a cyano, a trifluoromethyl radical, a trifluoromethoxy radical, an S(O)nAlk group, a (C1-C4)alkylcarbonyl group, and methylenedioxy;
• or substituents chosen from phenyl, phenoxy, pyrrolyl, imidazolyl, pyridyl and pyrazolyl radical, said radicals being unsubstituted or substituted once or several times with a (C1-C4)alkyl;
• a benzyl which is mono- or disubstituted on the phenyl with substituents independently chosen from a halogen atom, a (C1-C4)alkyl, a (C1-C4)alkoxy, a trifluoromethyl radical, and (trifluoromethyl)thio radical;
• or the phenyl substituted at the alpha-position with one or two similar or different groups chosen from a (C1-C4)alkyl, a (C3-C7)cycloalkyl, or a pyrrolyl radical;
• a phenethyl which is unsubstituted or mono- or disubstituted on the phenyl with substituents independently chosen from the halogen atom, a (C1-C4)alkyl, a (C1-C4)alkoxy, and a trifluoromethyl radical;
• a 1, 2, 3, 4-tetrahydronaphthyl or a 5, 6, 7, 8-tetrahydronaphthyl which is unsubstituted or mono- or disubstituted with substituents independently chosen from a (C1-C4)alkyl, a (C1-C4)alkoxy and a trifluoromethyl radical;
• a benzhydryl;
• or a benzhydrylmethyl;
• R2 represents a hydrogen atom or a (C1-C3)alkyl;
• R3 represents a phenyl which is unsubstituted or mono-, di- or trisubstituted with substituents independently chosen from a halogen atom, a (C1-C4)alkyl, a (C1-C4)alkoxy, a trifluoromethyl radical or an S(O)nAlk group;
• R4 represents a phenyl which is unsubstituted or mono-, di- or trisubstituted with substituents independently chosen from a halogen atom, a (C1-C4)alkyl, a (C1-C4)alkoxy, a trifluoromethyl radical or an S(O)nAlk group;
• R5 represents a hydrogen atom or a (C1-C3)alkyl;
• n represents 0, 1 or 2;
• and
• Alk represents a (C1-C4)alkyl.