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AssigneesGian Franco Bottazzo, Mattia Locatelli, Lamya Al-Saqqaf
InventorsGian Franco Bottazzo, Mattia Locatelli
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An in vitro method for predicting the onset of type 1 diabetes (T1 D) in a subject, comprises the steps of: (a) measuring the concentration of at least one amino acid, amino acid derivative or amino acid metabolite in a biological sample taken from the subject; (b) determining the subject's HLA genotype; (c) assigning the subject's genetic risk of developing T1 D on the basis of the subject's HLA genotype; (d) combining the information obtained in step (a) with the information in step (c); and (e) predicting the likelihood of onset of T1 D based upon the combination of step (d). The diagnostic method can be used to select target subjects for T1 D prophylactic treatment, and as part of a T1 D preventative treatment regime for neonates having a likelihood of developing childhood T1 D.
1-44. (canceled)
A composition comprising;
A composition according to claim 1, wherein the one or more amino acids, amino acid derivatives or amino acid metabolites are selected from the group consisting of alanine, arginine, asparagines, aspartate, cysteine, glutamate, glutamine, glycine and histidine.
An in vitro method for predicting the onset of T1D in a subject comprising the steps of:
Dependencies are inferred from the claim text.